Science : Biochemistry

This volume highlights the remarkable superfamily of molecular motors called myosins, which are involved in such diverse cellular functions as muscle contraction, intracellular transport, cell migration and cell division. In a timely compilation of chapters written by some of the leading research groups in the world that have made key discoveries in the field, the current understanding of the molecular mechanisms and biological functions of these intriguing proteins is explored. The different myosin classes are compared and contrasted in the introductory chapter, as well as chapters on myosin structure; and biochemical and kinetic properties of myosins. Subsequent chapters are devoted to single classes of myosins and provide keen insight based on studies using in vitro and in vivo systems into how particular myosins are designed for their intracellular roles. This highly authoritative and comprehensive volume includes current information on myosin mutations, which are responsible for diseases such as cardiomyopathies, immunodeficiences and neurological disorders, as well as hearing and vision defects. Written in an intelligible and coherent manner and presented in a format such that minimal background knowledge is needed, this indexed volume will be useful not only to those interested in learning about molecular motors, but as a crucial reference for researchers. more...

Price: $199.00

This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time. more...

Price: $190.00

Featuring an analysis of ABC Proteins, this book discusses and compares evolution, biology and mechanism of action of known ABC proteins, including the structural studies as well as clinical implications. more...

Price: $210.00

Optimization problems occurring regularly in chemistry, vary from selecting the best wavelength design for optimal spectroscopic concentration predictions to geometry optimization of atomic clusters and protein folding. Numerous optimization tactics have been explored to solve these problems. While most optimizers maintain the ability to locate global optima for simple problems, few are robust against local optima convergence with regard to difficult or large scale optimization problems. Simulated annealing (SA) has shown a great tolerance to local optima convergence and is often called a global optimizer. The optimizaton algorithm has found wide use in numerous areas such as engineering, computer science, communication, image recognition, operation research, physics, and biology. Recently, SA and variations thereof have shown considerable success in solving numerous chemical optimization problems. The main thrust of this book is to demonstrate the use of SA in a wide range of chemical problems. The potentiality of SA, GSA and other modifications of SA to serve specific needs in a variety of chemical disciplines are covered. A detailed discussion on SA and GSA is given in Chapter 1, presenting the theoretical framework from which a computer program can be written by the reader. The remainder of the book describes applications of SA type algorithms to a diverse set of chemical problems. The final chapter contains an algorithm for GSA written in the MatLab programming environment. This program can be easily adapted to any optimization problem and with only slight modifications, can be altered to perform SA. A general flowchart is also given. more...

Price: $302.50

A volume of indispensable methods for the use of transposons and phage in genomic engineering. more...

Price: $149.95